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Inside of a examine in breast cancer cells, The mix of lapatinib, a dual HER2/neu and EGFR tyrosine kinase inhibitor, with INK128 prevented equally HER2 and HER3 phosphorylation induced by INK128 and created synergistic induction of cell Demise in various HER2-optimistic mobile traces immune to trastuzumab and lapatinib. In vivoMeanwhile, to ensure